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SUMMARY:From Gene Networks to Tissue Engineering: Computational Models of 
 Pattern Formation - Dagmar Iber\, Computational Biology ETH Zurich
DTSTART:20110707T100000Z
DTEND:20110707T110000Z
UID:TALK31980@talks.cam.ac.uk
CONTACT:Microsoft Research Cambridge Talks Admins
DESCRIPTION:Limb bud development has long served as a paradigm of organoge
 nesis and pattern formation. Decades of genetic and biochemical studies pr
 ovide us with a wealth of information about the molecular circuits that co
 ntrol cell expansion andposition-dependent cell differentiation in the dev
 eloping limb bud. In spite of much detailed biological knowledge and much 
 theoretical work a detailed mechanistic understanding of how the genes and
  regulatory circuits interact to control limb organogenesis is still lacki
 ng. In collaboration with the Zeller group at the Department of Biomedicin
 e of the University of Basel we are developing detailed computational mode
 ls for limb development in mice. By combining mathematical modeling with e
 xperimentation we seek to understand how key processes at the microscopic 
 level interact to give rise to patterning at the macroscopic level.\n\nThe
  signaling pathways (Fgf\, Shh\, Bmp\, Gremlin) that regulate limb bud dev
 elopment are strikingly similar to those that regulate lung morphogenesis.
  Based on the model for limb development we have also developed a mechanis
 tic model for the regulatory network that governs lung branching. The bran
 ching of the bronchi in the lungs is highly stereotyped and results from a
  highly regulated process that restricts the types and sequence of branchi
 ng modes.\n\nIn the long run we seek to use our mechanistic insights in th
 e engineering of tissue and bone.\n
LOCATION:Small lecture theatre\, Microsoft Research Ltd\, 7 J J Thomson Av
 enue (Off Madingley Road)\, Cambridge
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