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SUMMARY:Drugging the cancer genome - Prof. Paul Workman\, Institute of Can
 cer Research\, Surrey
DTSTART:20120313T130000Z
DTEND:20120313T140000Z
UID:TALK32008@talks.cam.ac.uk
CONTACT:Luca Pellegrini
DESCRIPTION:Professor Paul Workman is Harrap Professor of Pharmacology and
  Therapeutics at The Institute of Cancer Research (ICR) and Director of th
 e ICR's Cancer Research UK Cancer Therapeutics Unit (CTU). He is also Depu
 ty CEO of the ICR and Head of its Division of Cancer Therapeutics. He lead
 s a large interdisciplinary research team that has been responsible for th
 e discovery of 16 new drug candidates over the last 6 years\, with 6 enter
 ing Phase I trials in ICR's partner hospital the Royal Marsden in the last
  2 years\, and abiraterone gaining regulatory approval in late stage prost
 ate cancer. Paul's research interests are in the design and application of
  chemical probes\, the discovery and development of molecular cancer thera
 peutics aimed at 'drugging the cancer genome' and the development of perso
 nalized molecular medicines for cancer. Alongside drug discovery\, Paul ha
 s led research to identify and utilize predictive and pharmacodynamic biom
 arkers and originated the now widely used concept of the 'pharmacological 
 audit trail.' In this lecture he will outline the strategic approach to dr
 ug discovery taken in the non-profit CTU\, then briefly exemplify this wit
 h reference to abiraterone\, PI3 kinase and AKT/PKB inhibitors\, and final
 ly review in detail the progress of HSP90 molecular chaperone inhibitors f
 rom natural product tools to the discovery in CTU/Vernalis of VER-52296/NV
 P-AUY922 which is now in Phase II clinical trial having been licensed to N
 ovartis. This is story that encapsulates all of the key elements of modern
  drug discovery and development\, including structure-based design and bio
 marker-led clinical trials. Current and future challenges in drugging the 
 cancer genome will be discussed.
LOCATION:Biochemistry Lecture Theatre\, Sanger Building\, Tennis Court Roa
 d
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