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SUMMARY:Biophysical Complexities of Polyglutamine Aggregation - Prof. Rohi
 t V. Pappu\, Department of Biomedical Engineering and Director\, Center fo
 r Biological Systems Engineering\, Washington University\, St. Louis\, USA
DTSTART:20110706T140000Z
DTEND:20110706T150000Z
UID:TALK32023@talks.cam.ac.uk
CONTACT:M. Madan Babu
DESCRIPTION:Nine different neurodegenerative disorders including Huntingto
 n's disease are associated with polyglutamine expansions. In vivo\, protei
 ns with polyglutamine expansions are unstable and are processed by proteol
 ysis. Fragments of proteolysis are rich in aggregation-prone polyglutamine
 . Recent results suggest that the mechanisms by which polyglutamine-rich f
 ragments aggregate are rather complex and these complexities derive from t
 he role of polyglutamine length and sequence context. This talk will prese
 nt some of these complexities that have been discovered using a series of 
 biophysical studies including atomistic simulations\, spectroscopy\, and p
 olymer physics theories. Implications for the role of polyglutamine aggreg
 ation in neurodegeneration will also be discussed. 
LOCATION:Structural Studies Seminar Room\, MRC Laboratory of Molecular Bio
 logy\, Cambridge\, UK
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