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SUMMARY:Cancer Gene Discovery in the Mouse - Dr David Adams\, Wellcome Tru
 st Sanger Institute
DTSTART:20111101T120000Z
DTEND:20111101T130000Z
UID:TALK32182@talks.cam.ac.uk
CONTACT:Dr Ireena Dutta
DESCRIPTION:Although we are large multi-cellular organisms with a long lif
 espan cancers form relatively rarely suggesting there are many growth cont
 rols checkpoints that restrain tumourigenesis. A corollary to this is that
  in most cancer types there are a limited number of genes that are frequen
 tly mutated but also many other genes that have been identified as potenti
 ally contributing to tumourigenesis. How these genes interact to drive tum
 our formation\, the sequence of mutations required for tumour formation\, 
 and the complete repertoire of cancer driver genes is largely unknown. In 
 this talk I will give several examples of how we are using the mouse to id
 entify cancer driver genes and to understand how they interact in driving 
 tumour formation.
LOCATION:Max Perutz Lecture Theatre\, MRC LMB
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