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SUMMARY:Neo-adjuvant radiochemotherapy in breast cancer - Dr Alain Fourque
 t\, Department of Radiation Oncology\, Institut Curie\, Paris
DTSTART:20111213T120000Z
DTEND:20111213T130000Z
UID:TALK32186@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:*Neo-adjuvant radiochemotherapy in breast cancer*\n\nNeaoadjuv
 ant chemotherapy is currently offered to women with breast cancer too larg
 e to undergo breast-conserving surgery. Several randomised trials have dem
 onstrated that neoadjuvant chemotherapy could allow a large proportion of 
 women to preserve their breast\, without  impairing survival in comparison
  to mastectomy followed by adjuvant chemotherapy.\nRadiotherapy in a neoad
 juvant setting has been used in the 70's and ealy 80's. A prospective rand
 omised study had shown similar results between radiotherapy followed by ma
 stectomy\, or mastectomy followed by radiotherapy.\nConcurrent radiochemot
 herapy has demonstrated survival benefits in various tumor locations\, suc
 h as oesophagus\, anal canal\, uterine cervix\, lung\, and head and neck. 
 Two prospective randomised trials have shown that  the  concurrent deliver
 y of radiotherapy and chemotherapy following breast-conserving surgery sig
 nificantly reduced locoregional recurrence rates in patients with pN+ve tu
 mors\, in comparison with a sequential scheme.  Concurrent neoadjuvant rad
 iochemotherapy was used in the past in patients with locally advanced or i
 nflammatory breast cancer with good clinical results in some.\nMore recent
 ly\, several phase II trials have investigated the efficacy of neoadjuvant
  concurrent radiotherapy and various chemotherapy combinations.\nThis  tal
 k will present the results from Institut Curie series and review the avail
 able data in the literature. It will discuss the potential of concurrent r
 adiochemotherapy schemes\, and the interest of the use of targeted therapi
 es with radiotherapy in breast cancer. \n\n
LOCATION:CRI Lecture Theatre
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