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SUMMARY:Genetic Screens in Embryonic Stem Cells - Professor Allan Bradley\
 , Director Emeritus\, Wellcome Trust Sanger Institute\, Cambridge
DTSTART:20120305T193000Z
DTEND:20120305T210000Z
UID:TALK32255@talks.cam.ac.uk
CONTACT:Dr Nigel Bennee
DESCRIPTION:In 1984 Liz Robertson and I demonstrated that embryonic stem (
 ES) cells could be transmitted through the germ line of mice and two years
  later reported that ES cells could be used to generate mice with mutation
 s in endogenous genes. This work contributed to the award of the Nobel Pri
 ze in Physiology or Medicine to Martin Evans in 2007.\n\nMice can be gener
 ated with changes as subtle as an alteration in a single nucleotide or as 
 massive as the deletion\, duplication or inversion of millions of base pai
 rs\, a technology that has become known as chromosome engineering. My labo
 ratory has used ES cell technology extensively\, generating and analysing 
 many of the first generation of mouse knockouts as well as helping numerou
 s other laboratories to utilize this technology. This work has provided ke
 y functional information on many genes with an emphasis on cancer\, DNA re
 pair and embryonic development.
LOCATION:Wolfson Lecture Theatre\, Churchill College\, Storey's Way\, Camb
 ridge
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