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SUMMARY:Optimal design of clinical trials in Alzheimer's disease - Ueckert
 \, S (Uppsala)
DTSTART:20110810T100000Z
DTEND:20110810T104500Z
UID:TALK32311@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Clinical trials in Alzheimer's disease are long\, costly and h
 ave a low success rate. In this setting\, optimal design theory constitute
 s a valuable tool to help planning of clinical studies efficiently. Our wo
 rk presents how the theory of optimal design can be applied to a complex s
 ituation like an Alzheimer's trial. We illustrate how to handle challenges
  like dropout\, covariate relationships and clinically relevant constraint
 s. Furthermore\, we illustrate how clinical trials can be directly optimiz
 ed for drug effect detection power.\n
LOCATION:Seminar Room 1\, Newton Institute
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