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SUMMARY:Bridging the Gap: Computational Biology and Trafficking of MHC Cla
 ss I - Professor Sebastian Springer\, Jacobs University\, Bremen\, hosted 
 by John Trowsdale
DTSTART:20111007T120000Z
DTEND:20111007T130000Z
UID:TALK32316@talks.cam.ac.uk
CONTACT:Liz Williams
DESCRIPTION:The surface expression of MHC class I molecules at least parti
 ally depends on the endoplasmic reticulum protein\, tapasin\, which helps 
 them bind peptides of the appropriate length and sequence. Why do class I 
 molecules need tapasin? We have used molecular dynamics\, a novel in silic
 o approach\, to generate a hypothesis\, and then tested it using biochemic
 al and cell biological methods. The surprising finding is that some class 
 I molecules are intrinsically disordered unless tapasin structures their b
 inding site. A comprehensive unifying scheme of tapasin function that take
 s other data from the literature into account will be presented\, and impl
 ications for the cellular quality control of MHC class I will be discussed
 . \n
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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