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SUMMARY:Dose Selection Incorporating PK/PD Information in Early Phase Clin
 ical Trials. - Bogachka\, B (QMUL)
DTSTART:20110815T153500Z
DTEND:20110815T161500Z
UID:TALK32354@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Early phase clinical trials generate information on pharmacoki
 netic parameters and on safety issues. In addition\, a dose level\, or a s
 et of dose levels\, needs to be selected for further examination in later 
 phases. If patients\, rather than healthy volunteers\, take part in the ea
 rly phase\, it may be possible to observe the effects of the drug on the d
 isease. \n\nIn the presentation we will discuss some statistical\, ethical
  and economic aspects of designing optimum adaptive clinical trials for do
 se selection incorporating both pharmacokinetic and pharmacodynamic endpoi
 nts. \n\n\n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
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