BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Jointly optimal design of Phase II and Phase III clinical trials: 
 an over-arching approach - Jennison\, C (Bath)
DTSTART:20110816T093000Z
DTEND:20110816T100000Z
UID:TALK32377@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:We consider the joint design of Phase II and Phase III trials.
  We propose a decision theoretic formulation with a gain function arising 
 from a positive Phase III outcome and costs for sampling and for time take
 n to reach a positive conclusion. With a prior for the dose response model
  and a risk curve for the probability that doses fail on safety grounds\, 
 the challenge is to optimise the design for comparing doses in Phase II\, 
 the choice of dose or doses to take forward to Phase III\, and the Phase I
 II design. We shall show it is computationally feasible to tackle this pro
 blem and discuss possible generalisations from an initial\, simple formula
 tion.\n
LOCATION:Seminar Room 1\, Newton Institute
END:VEVENT
END:VCALENDAR