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SUMMARY:Dose Escalation using a Bayesian Model: rational decision rules. -
  Thygesen\, H (Lancaster)
DTSTART:20110816T133000Z
DTEND:20110816T140000Z
UID:TALK32382@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:In dose escalation studies\, the potential ethical costs of ad
 ministering high doses must be weighted against the added utility from gai
 ning safety information about high (and potentially effective doses). This
  is the rationale for starting with low doses while the confidence in the 
 safety of the drug is low\, and escalating to higher doses as confidence g
 row. A decision theoretical framework is proposed.\n
LOCATION:Seminar Room 1\, Newton Institute
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