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SUMMARY:Systematic review of the use of stepped wedge cluster randomized t
 rials - Taylor\, C (Birmingham)
DTSTART:20110817T100000Z
DTEND:20110817T104500Z
UID:TALK32395@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Background In a stepped wedge cluster randomized controlled tr
 ial\, clusters are randomly allocated to the order in which they will rece
 ive the intervention\, with one cluster receiving the intervention at the 
 beginning of each study period (step). Therefore by the end of the recruit
 ment period all clusters have received the intervention\, but the number o
 f periods in the control and intervention sections of the wedge will vary 
 across clusters. \n\nObjective To describe the application of the stepped 
 wedge cluster randomized controlled trial design using a systematic review
 . \n\nStudy Design and Setting We searched MEDLINE\, EMBASE\, PSYCINFO\, H
 MIC\, CINAHL\, Cochrane Library\, Web of Knowledge and Current Controlled 
 Trials Register for articles published up to January 2010. Stepped wedge c
 luster randomized controlled trials from all fields of research were inclu
 ded. Two authors independently reviewed and extracted data from the studie
 s. \n\nResults Twenty five studies were included in the review. Motivation
 s for using the design included ethical\, logistical\, financial\, social 
 and political acceptability and methodological reasons. Most studies were 
 evaluating an intervention during routine implementation. For most of the 
 included studies there was also a belief or empirical evidence suggesting 
 that the intervention would do more good than harm. There was variation in
  data analysis methods and insufficient quality of reporting. \n\nConclusi
 ons The stepped wedge cluster randomized controlled trial design has been 
 mainly used for evaluating interventions during routine implementation\, p
 articularly for interventions that have been shown to be effective in more
  controlled research settings\, or where there is lack of evidence of effe
 ctiveness but there is a strong belief that the intervention will do more 
 good than harm. There is need for consistent data analysis and reporting. 
 \n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
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