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SUMMARY:Theoretical insights into co-translational folding: From pathways 
 to proteomes - Dr Edward O'Brien
DTSTART:20111104T120000Z
DTEND:20111104T130000Z
UID:TALK32397@talks.cam.ac.uk
CONTACT:Dr Mark Miller
DESCRIPTION:Understanding protein folding <i>in vivo</i> and protein homeo
 stasis in living cells requires we understand the concomitant folding of p
 roteins during their biosynthesis by the ribosome molecular machine.  I wi
 ll discuss our efforts to understand the principles of such co-translation
 al folding through the development of coarse-grained simulation force-fiel
 ds\, chemical kinetic modelling\, and systems biology methods. These tools
  have allowed us to gain novel insights into fundamental issues in <i>in v
 ivo</i> folding including the impact of variable translation rates\, the e
 ffect of chaperones\, and the co-translational folding properties of the <
 i>E. coli</i> proteome.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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