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SUMMARY:A Bayesian Adaptive Design with Biomarkers for Targeted Therapies 
 and Some Commentary on Adaptive Designs - Kim\, K (Wisconsin)
DTSTART:20110818T134500Z
DTEND:20110818T143000Z
UID:TALK32402@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Pharmacogenomic biomarkers are considered an important compone
 nt of targeted therapies as they can potentially be used to identify patie
 nts who are more likely to benefit from them. New study designs may be hel
 pful which can evaluate both the prognosis based on the biomarkers and the
  response from targeted therapies. In this talk I will present a recently 
 developed Bayesian response-adaptive design. The design utilizes individua
 l pharmacogenomic profiles and clinical outcomes as they become available 
 during the course of the trial to assign most effective treatment to patie
 nts. I will present simulation studies of the proposed design. In closing 
 I will share my perspectives on adaptive designs in general.\n
LOCATION:Seminar Room 1\, Newton Institute
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