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SUMMARY:An efficient alternative to the complete matched-pairs design for 
 assessing non-inferiority of a new diagnostic test - van de Ven\, P (Vrije
  U\, Amsterdam)
DTSTART:20110818T104500Z
DTEND:20110818T113000Z
UID:TALK32405@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Studies for assessing non-inferiority of a new diagnostic test
  relative to a standard test typically use a complete matched-pairs design
  in which results for both tests are obtained for all subjects. We present
  alternative non-inferiority tests for the situation where results for the
  standard test are obtained for all subjects but results for the new test 
 are obtained for a subset of those subjects only. This situation is common
  when results for the standard test are available from a monitoring or scr
 eening programme or from a large biobank. A stratified sampling procedure 
 is presented for drawing the subsample of subjects that receive the new di
 agnostic test with strata defined by the two outcome categories of the sta
 ndard test. Appropriate statistical tests for non-inferiority of the new d
 iagnostic test are derived. We show that if diagnostic test positivity is 
 low\, the number of subjects to be tested with the new test is minimized w
 hen stratification is non-proportional.\n
LOCATION:Seminar Room 1\, Newton Institute
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