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SUMMARY:Endosomal Feedback at the T-cell Immune Synapse - Dr Marco Purbhoo
 \, Dept of Medicine\, Imperial College London
DTSTART:20111019T113000Z
DTEND:20111019T123000Z
UID:TALK32552@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:How T cell activation is regulated on the molecular level at t
 he immune synapse remains of central interest to immunology. This process 
 involves complex dynamic interactions between cell-surface receptors\, adh
 esion molecules\, signal transduction elements\, and cytoskeletal proteins
 \, but remains incompletely understood.\n\nIntracellular vesicular compart
 ments are involved in removing spent receptors from the immune synapse\, a
 s well as directing specialized cargo to the synapse for release towards t
 arget cells. Whether intracellular vesicles are also involved in the activ
 ating processes at the immune synapse during T cell signalling remains unk
 nown.  \n\nWe here describe membrane-proximal endosomal vesicles which are
  intimately involved with the architecture of the immune synapse. These su
 b-synaptic vesicles can interact with surface microclusters of signalling 
 proteins during T cell activation\, and in doing so\, boost the signalling
  capacity of individual microclusters. Thus docking of sub-synaptic vesicl
 es to microclusters at the plasma membrane through an intracellular adhesi
 on event may complete signal¬ling complexes during T cell activation.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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