BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Dissecting signals of genetic association to complex diseases with
 in the HLA - Professor Gilean McVean\, University of Oxford
DTSTART:20111109T123000Z
DTEND:20111109T133000Z
UID:TALK32554@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Large-scale association studies\, now often consisting of coho
 rts of over 10\,000 individuals\, have the potential to aid greatly our un
 derstanding of the genetic risks to complex disease associated with classi
 cal HLA and other types of variation within the human MHC .\n\nHowever\, g
 enotyping samples at HLA loci using experimental techniques is time-consum
 ing and costly and currently not feasible on such a scale. We have develop
 ed techniques for statistical imputation and analysis of classical HLA all
 eles from SNPs that are typed on standard genotyping platforms.\n\nI will 
 discuss the strengths and weaknesses of imputation-based studies\, focusin
 g on recent analyses of autoimmune diseases within the Wellcome Trust Case
  Control Consortium.  In particular I will show how imputation was used to
  dissect signals of association to multiple sclerosis within the HLA.  I w
 ill also describe statistical and computational methods that we are develo
 ping to enable the use of high throughput sequencing data to characterise 
 genetic variation within and beyond the classical HLA loci.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
END:VEVENT
END:VCALENDAR