BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:A genome-wide consideration of genes controlling MHC class II func
 tion and beyond - Professor Jacques Neefjes\, Netherlands Cancer Institute
DTSTART:20111116T123000Z
DTEND:20111116T133000Z
UID:TALK32555@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:MHC class II molecules present antigenic fragments to CD4 T ce
 lls and thus control a plethora of immune responses. The cell biology of M
 HC class II is also of interest as it enters the endosomal pathway to acqu
 ire antigenic fragments before moving to the plasma membrane for presentat
 ion. \n\nWe will describe two aspect related to the transport of MHC class
  II molecules. This involves the Rab7-RILP associated dynein motor and the
  mode of control of late endosomal vesicle fusion. We show how these proce
 sses are controlled by proteins on another compartments (the ER) and how t
 his is finally controlled by cholesterol. In addition\, we aimed to identi
 fy processes controlling MHC class II transport in dendritic cells where t
 hey are surface deposited following activation. We have performed an siRNA
  screen and –after secondary screens and expression profiling- predicted
  a number of candidate proteins involved in the control of MHC class II tr
 ansport in dendritic cells. We show how this is used to define new pathway
 s that explain how MHC class II is controlled involving a new GTPase ARF7 
 and the myosin motor 1E.\n\nIntegrating high content screens with imaging\
 , protein chemistry and other techniques allows definition of new pathways
  controlling MHC class II molecules. \n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
END:VEVENT
END:VCALENDAR