BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Protective immunity in HIV infection? A tale of two villages - Pro
 fessor Sarah Rowland-Jones\, University of Oxford
DTSTART:20111123T123000Z
DTEND:20111123T133000Z
UID:TALK32556@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Despite three decades of research\, the correlates of protecti
 ve immunity against HIV infection remain poorly defined\, which poses a si
 gnificant barrier to HIV vaccine development. I will present data from imm
 unological and virological studies of two very different village cohorts w
 e have studied in an effort to understand better the factors associated wi
 th delayed HIV disease progression. \n\nThe first is a remote community in
  rural Guinea-Bissau which is home to a community cohort of people with HI
 V-2 infection that has been followed for over 20 years: the majority of HI
 V-2-infected people behave as long-term non-progressors (LTNPs) and mainta
 in a viral load below detection for many years\, whereas the progressors a
 re clinically indistinguishable from progressors with HIV-1. \n\nThe secon
 d cohort in central China became infected with HIV-1 through a contaminate
 d plasma donor scheme in the mid 1990s that led to infection with a very n
 arrow range of viruses: this scenario allows a clear analysis of the host 
 selection pressures on the infecting virus over time\, and shows how much 
 selection is imposed in association with HLA class I and KIR molecules in 
 the infected individuals.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
END:VEVENT
END:VCALENDAR