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SUMMARY:Universal laws\, architectures\, and behaviors of robust\, evolvab
 le networks - John Doyle (Caltech)
DTSTART:20110912T130000Z
DTEND:20110912T140000Z
UID:TALK32742@talks.cam.ac.uk
CONTACT:Dr Ioannis Lestas
DESCRIPTION:This talk will review recent progress on developing a “unifi
 ed” theory for\ncomplex networks involving several elements: hard limits
  on achievable robust\nperformance (misnamed “laws”)\, the organizing 
 principles that succeed or fail\nin achieving them (architectures and prot
 ocols)\, the resulting high variability\ndata and “robust yet fragile”
  behavior observed in real systems and case\nstudies (behavior\, data)\, a
 nd the processes by which systems evolve (variation\,\nselection\, design)
 .  The talk will focus on the results in a recent paper on\nglycolytic osc
 illations [7]\, and on a framework for network architecture as\ndescribed 
 briefly in [4]\, [5]\, [8]\, with some discussion of representative case\n
 studies [1]- [9].\n\nInsights into what the potential universal laws\, arc
 hitecture\, and\norganizational principles are can be drawn from three con
 verging research\nthemes. First\, detailed description of components and a
  growing attention to\nsystems in biology and neuroscience\, the organizat
 ional principles of organisms\nand evolution are becoming increasingly app
 arent [1][7][8].  Biologists are\narticulating richly detailed explanation
 s of biological complexity\, robustness\,\nand evolvability that point to 
 universal principles and architectures. Second\,\nwhile the components dif
 fer and the system processes are far less integrated\,\nadvanced technolog
 y’s complexity is now approaching biology’s and there are\nstriking co
 nvergences at the level of organization and architecture\, and the\nrole o
 f layering\, protocols\, and feedback control in structuring complex\nmult
 iscale modularity [2][5].  Third\, new mathematical frameworks for the stu
 dy\nof complex networks suggests that this apparent network-level evolutio
 nary\nconvergence within/between biology/technology is not accidental\, bu
 t follows\nnecessarily from their universal system requirements to be fast
 \, efficient\,\nadaptive\, evolvable\, and most importantly\, robust to pe
 rturbations in their\nenvironment and component parts [4].  We have the be
 ginnings of the underlying\nmathematical framework and also a series of ca
 se studies in classical problems\nin complexity from statistical mechanics
  [6]\, turbulence [9]\, cell biology [1][7]\,\nhuman physiology and medici
 ne\, neuroscience [8]\, wildfire ecology [3]\,\nearthquakes\, economics\, 
 the Internet [2][4][5]\, and smartgrid.   The talk will\nbriefly review so
 me aspects of these case studies.\n\n\n\nSelected references:\n\n[1]    H.
  El-Samad\, H. Kurata\, J.C. Doyle \, C.A. Gross\, and M. Khammash\,\n(200
 5)\, Surviving Heat Shock: Control Strategies for Robustness and\nPerforma
 nce\, P Natl Acad Sci USA 102(8): FEB 22\, 2005\n\n[2]    Doyle et al\, (2
 005)\, The “Robust Yet Fragile” Nature of the Internet\, P\nNatl Acad 
 Sci USA 102 (41)\, October 11\, 2005\n\n[3]    MA Moritz\, ME Morais\, LA 
 Summerell\, JM Carlson\, J Doyle (2005)\nWildfires\, complexity\, and high
 ly optimized tolerance\, P Natl Acad Sci USA\, 102\n(50) December 13\, 200
 5\; \,\n\n[4]    M Chiang\, SH Low\, AR Calderbank\, JC. Doyle (2006) Laye
 ring As\nOptimization Decomposition\, PROCEEDINGS OF THE IEEE\, Volume: 95
   Issue: 1  Jan\n2007\n\n[5]    Alderson DL\, Doyle JC (2010) Contrasting 
 views of complexity and their\nimplications for network-centric infrastruc
 tures. IEEE Trans Systems Man\nCybernetics—Part A: Syst Humans 40:839-85
 2.\n\n[6]    H. Sandberg\, J. C. Delvenne\, J. C. Doyle. On Lossless Appro
 ximations\,\nthe Fluctuation-Dissipation Theorem\, and Limitations of Meas
 urements\, IEEE\nTrans Auto Control\, Feb 2011\n\n[7]    Chandra F\, Buzi 
 G\, Doyle JC (2011) Glycolytic oscillations and limits on\nrobust efficien
 cy. Science\, Vol 333\, pp 187-192.\n\n[8]    JC Doyle\, ME Csete (2011) A
 rchitecture\, Constraints\, and Behavior\, P\nNatl Acad Sci USA\, in press
 \, available online\n\n[9]    Gayme DF\, McKeon BJ\, Bamieh B\, Papachrist
 odoulou P\, Doyle JC (2011)\nAmplification and Nonlinear Mechanisms in Pla
 ne Couette Flow\, Physics of\nFluids\, in press (published online 17 June 
 2011)\n
LOCATION:Cambridge University Engineering Department\, LR5
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