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SUMMARY:Changes in cell and tissue architecture in early stages of colorec
 tal cancer - Professor Inke Näthke - Dundee Cancer Centre\, University of
  Dundee
DTSTART:20111103T143000Z
DTEND:20111103T153000Z
UID:TALK32848@talks.cam.ac.uk
CONTACT:Becky Baglow
DESCRIPTION:Changes in epithelial organisation accompany a range of human 
 diseases from acute and chronic inflammatory conditions\, bacterial infect
 ions\, parasitic colonization and cancer.  Understanding how epithelia are
  normally maintained and how molecular changes govern cellular and tissue 
 changes in disease is necessary to develop effective treatments and detect
 ion methods.  My research aims to understand the mechanisms that govern ph
 ysiology of epithelial tissues\, particularly gut epithelium\, in health a
 nd disease.\nThe Adenomatous Polyposis Coli (APC) protein is a key regulat
 or of normal epithelial architecture and physiology in the gut.  APC is mu
 ltifunctional protein with many binding partners that link it to signaling
  pathways that determine the properties and functions of epithelial cells 
 and tissues.  We use the contributions of APC to gut tissue maintenance as
  a paradigm for understanding the earliest changes that occur in disease p
 rogression\, particularly cancer.  \nUsing high resolution imaging of whol
 e tissue we have discovered novel architectural features of healthy and pr
 ecancerous gut tissue.  This includes continuous muscle-like structures th
 at support intestinal tissue units and align with the outer muscle layer o
 f the gut\, changes in tissue shape that correlates with altered alignment
  of mitotic spindles specifically in stem cells\, decreased cell migration
 \, and corresponding accumulation of cells in a precancerous condition.  I
  will discuss the implications of these changes but also their link to cel
 l biological and biochemical consequences of the mutations that produce th
 em.\n
LOCATION:Part II room\,  Department of Genetics
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