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SUMMARY:Mechanisms and regulation of DNA recombination during meiosis - Ma
 tthew Neale - MRC Genome Damage and Stability Centre\, University of Susse
 x
DTSTART:20111124T143000Z
DTEND:20111124T153000Z
UID:TALK32849@talks.cam.ac.uk
CONTACT:Becky Baglow
DESCRIPTION:Summary:\nThe maintenance of genetic information and its accur
 ate transmission from one generation to the next are essential processes f
 or organisms to survive and populate. Errors in this process must be corre
 cted\, and cells have evolved various means to repair any damage to chromo
 somal DNA that may arise over time.\n\nIn my lab\, we study the process of
  homologous recombination (HR)—a potentially error-free DNA repair pathw
 ay that works by copying information from intact DNA sequences present els
 ewhere in the genome. HR is used extensively in meiotic cells to repair DN
 A breaks that are purposely created by the cell. In this context\, HR is n
 ot just a repair mechanism\, but also a method to drive interaction and ge
 netic exchange between maternally and paternally inherited chromosomes\, c
 reating haploid genomes that are chimeras of the parental genetic informat
 ion.\n\nIn this seminar I will describe the findings of our recent researc
 h\, which has focused on characterising initial events in the meiotic reco
 mbination DNA repair pathway.\n\nLab web page: http://www.sussex.ac.uk/lif
 esci/nealelab/\n\nRecent publications: http://tinyurl.com/cbl9num
LOCATION:Part II room\,  Department of Genetics
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