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SUMMARY:Using bespoke fluorescence microscopy to study the soft matter of 
 living cells at the single molecule level - Dr Mark Leake\, University of 
 Oxford\, UK
DTSTART:20111111T140000Z
DTEND:20111111T150000Z
UID:TALK33201@talks.cam.ac.uk
CONTACT:Tracy Inman
DESCRIPTION:The use of bespoke imaging tools and analysis can offer signif
 icant insight into the\nliving counterpart of soft condensed matter. The s
 oft matter of biological systems consists of molecular building blocks\, a
  staple of which is protein. Protein molecules\, so small that 1 billion w
 ould fit on the full-stop at the end of this sentence\, carry out most of 
 the vital activities in living cells. Many of these processes require the 
 assembly of multiple proteins into remarkable biological machines. Obtaini
 ng the blueprints for the architecture of these machines is essential for 
 understanding the workings of the cell. Here\, I will discuss recent biolo
 gical physics experiments on functional single-celled organisms in which o
 ne can apply bespoke fluorescence microscopy imaging and analysis to monit
 or the number and dynamics of several\ndifferent proteins at the nanometre
  length scale to a precision of single molecules. 1\n\n1. Reyes-Lamothe R\
 , Sherratt DJ\, Leake MC. Stoichiometry and architecture of active DNA rep
 lication machinery in Escherichia coli. Science. 2010\, 328\, 498-501.\n
LOCATION:Pippard Lecture Theatre\, Cavendish Laboratory
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