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SUMMARY:Understanding longevity: an epidemiological study of genetics\, di
 sease and life-style - Henning Tiemeier\, Professor of Psychiatric Epidemi
 ology at the Erasmus Medical Center\, Rotterdam
DTSTART:20111118T130000Z
DTEND:20111118T140000Z
UID:TALK33259@talks.cam.ac.uk
CONTACT:Dr Simon Richard White
DESCRIPTION:Public health scientists have contributed to an impressive gai
 n in average life expectancy\, epidemiologists have identified numerous de
 terminants of survival\, and in addition\, geneticists have demonstrated t
 hat longevity is heritable. Yet\, prediction of an individual’s life exp
 ectancy over long time periods\, an understanding of the mechanisms behind
  established risk factors for healthy ageing – such as obesity or well-b
 eing – and identification of the specific genetic variations related to 
 ageing have all remained elusive.  \n\nDr. Tiemeier will present a series 
 of his recent genetic and non-genetic epidemiological studies of longevity
  in the Rotterdam Study cohort (n=15\,000 persons\, 1990-2011). He will di
 scuss the obesity paradox and introduce studies of selected survival risk 
 factors\, e.g. happiness. The results of a several large GWA studies of lo
 ngevity\, which his group conducted\, are shown. Finally\, current analyse
 s are presented that demonstrate how well we can predict mortality if we i
 ntegrate GWA data and more than 100 established non-genetic risk factors. 
 Against this background he will discuss future opportunities and challenge
 s in epidemiological longevity research.\n\n
LOCATION:Large Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
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