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SUMMARY:Watching proteins fold and unfold one at a time. How physics can t
 each us lessons about biology - Prof. Jane Clarke\, Department of Chemistr
 y
DTSTART:20111125T180000Z
DTEND:20111125T191500Z
UID:TALK33352@talks.cam.ac.uk
CONTACT:Dr Xavier Moya
DESCRIPTION:Proteins are linear polymers made up of just 20 naturally occu
 rring\namino acids.  The genome projects produced a significant challenge 
 for those studying proteins:  we now know the linear\, one-dimensional seq
 uence of all proteins in the human body.  Contained in this sequence is al
 l the information required for the protein to fold to the correct\, "nativ
 e" structure\, in a timescale which is reasonable\, to perform a function 
 within the cell\, and\, equally importantly\, not to misfold to any altern
 ative\, possibly toxic\, structure. The study of protein folding seeks to 
 explain how proteins fold and avoid misfolding\, and how the folded struct
 ure gives the protein its function. We use the tools of physics and chemis
 try\, alongside those from molecular and structural biology.  I will descr
 ibe some of the recent progress we are making using methods that allow us 
 to investigate one molecule at a time.
LOCATION:Roger Needham Room\, Wolfson College
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