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SUMMARY:Signaling through the ubiquitin system - Wade Harper\, Harvard Med
 ical School
DTSTART:20111215T161500Z
DTEND:20111215T180000Z
UID:TALK34160@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Many signaling pathways employ covalent modification of target
  proteins by ubiquitin to control the timing of particular events. In orde
 r to more easily identify protein complexes and signaling networks\, we ha
 ve developed a bioinformatic and experimental platform that facilitates th
 e parallel analysis of interaction networks and ubiquitin modifications. W
 e have employed this platform to eluciduate the interaction landscape of s
 everal classes of proteins in the ubiquitin system\, including a large fra
 ction of human deubiquitinating enzymes\, E3 ubiquitin ligases\, and the a
 utophagy system. Recently\, we have developed technology that allows the i
 dentification of sites of ubiquitination of proteins on a large scale. We 
 employ this approach to examine how proteasome inhibition re-sculpts the u
 biquitinated proteome\, and the role of protein synthesis in this process.
  We also have demonstrated the utility of this approach in the identificat
 ion of substrates for ubiquitin ligases. These tools and technologies prov
 ide a facile system for understanding the complexities of the ubiquitin sy
 stem and its role in cell function.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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