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SUMMARY:Multi-scale studies on Drosophila transcription factors - Boris Ad
 ryan (CCBI\,Genetics)
DTSTART:20111130T140000Z
DTEND:20111130T150000Z
UID:TALK34409@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:Abstract: Transcription factors play a crucial role in the coo
 rdination of developmental gene expression programs. Our research concerns
  combinatorial aspects of transcription factor utilization in Drosophila\,
  looking at both the level of organismic co-expression as well as co-bindi
 ng to cis-regulatory modules. In this talk\, I am going to focus on two se
 emingly unrelated observations\, one concerning the constant reshuffling o
 f transcription factors to form new co-expression clusters during embryoni
 c development\, the other concerning the highly similar binding patterns o
 f different transcription factors in different tissues. I am going to pres
 ent evidence that comparing apples with pears (or diverse genome-wide bind
 ing profiles) sometimes does make sense in genome-scale computational anal
 yses\, and conclude with a hypothesis why that is on the basis of the afor
 ementioned seemingly unrelated observations.\n
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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