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SUMMARY:Modeling a single-site spring-like hypothesis for Fe-mediated N2 r
 eduction - Professor Jonas Peters\, California Institute of Technology
DTSTART:20111208T140000Z
DTEND:20111208T150000Z
UID:TALK34505@talks.cam.ac.uk
CONTACT:Sian Bunnage
DESCRIPTION:Our group has suggested previously that a hemi-labile role may
  be played by the interstitial light X-atom of the FeMo-cofactor\, enablin
 g a high degree of conformational and redox flexibility at a single iron N
 2 binding site. In this regard the central X-atom could act like a spring 
 as the iron site coordinates various reduced nitrogenous ligands during tu
 rnover. This scenario would allow the iron center to modulate its local ge
 ometry by varying its degree of interaction with the light X-atom under cr
 ude local three-fold symmetry\, possibly sampling trigonal bipyramidal\, t
 rigonal pyramidal\, and/or pseudotetrahedral geometries as a function of t
 he nature of the state of reduction of the nitrogenous ligand. Our group h
 as been exploring a range of 4- and 5-coordinate iron complexes that exhib
 it local three-fold symmetry and feature a host of nitrogenous ligands (e.
 g.\, N2\, N2H4\, NH3\, NH2-\, NR2-\, N3-) in an axial substrate-binding si
 te. These iron complexes will be discussed as simple inorganic models that
  can help us to consider and evaluate a single-iron site spring hypothesis
  for nitrogen reduction in biology.
LOCATION:Pfizer Lecture Theatre\, Department of Chemistry
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