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SUMMARY:Making candy for signal transduction research -  Adventures in Wil
 ly Wonka land - Prof Morten Grötli\, Department of Chemistry\, University
  of Gothenburg
DTSTART:20111124T110000Z
DTEND:20111124T120000Z
UID:TALK34739@talks.cam.ac.uk
CONTACT:Marko Hyvonen
DESCRIPTION:To investigate individual signalling proteins and pathways\, c
 hemical tools provide a powerful complement to existing genetic\, chemical
  genetic and immunologic methods. In particular\, understanding phosphoryl
 ation-mediated signalling in real time gives important information about t
 he regulation of cellular function and insights into the origin of disease
 . Our laboratory focuses on the development of novel chemically based tool
 s to decipher signal transduction pathways. These tools include novel\, fa
 st acting kinase inhibitors\, positional scanning peptide libraries for in
 vestigation of substrate specificity of kinases and fluorescent probes whi
 ch allow the study of intracellular localisation of kinases. The developme
 nt of some of these tools as well as examples of their applications will b
 e discussed.\n
LOCATION:Perham's seminar room
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