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SUMMARY:The Search for Organizing Principles in Cancer Systems Biology - O
 laf Wolkenhauer (University of Rostock\, www.sbi.uni-rostock.de)
DTSTART:20120116T160000Z
DTEND:20120116T170000Z
UID:TALK34784@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Cancer systems biology is an approach by which cancer-related 
 cell-biological questions are addressed through iterative cycles of data-d
 riven modelling and model-driven experimentation. In my presentation I sha
 ll review and point out limitations in the current practice of pathway-cen
 tric mechanistic modeling. This leads me to a new perspective that integra
 tes levels of structural and functional organization: from the molecular/c
 ell level to the tissue level\, from network models to multilevel systems\
 , from studying mechanisms to identifying organizing principles. Organizin
 g principles in systems biology are robust generalizations\, akin to natur
 al laws in physics or chemistry. I argue that the search for organizing pr
 inciples requires novel approaches and I shall give examples for the direc
 tion in which these new developments should go. \n\nwww.sbi.uni-rostock.de
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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