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SUMMARY:The chicken leukocyte receptor cluster - Professor Thomas Gobel\, 
 Ludwig Maximillian University\, Munich
DTSTART:20120125T123000Z
DTEND:20120125T133000Z
UID:TALK35122@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Receptors of the immunoglobulin-like superfamily are criticall
 y involved in virtually every aspect of immune responses.   One large chro
 mosomal area encoding such immunoregulatory receptors is the leukocyte rec
 eptor cluster.  \n\nI will review various aspects of the chicken Ig-like r
 eceptor (CHIR) family\, located on microchromosome 31\, an orthologous pos
 ition to the mammalian leukocyte receptor cluster.  The CHIR family has be
 en massively expanded with over a hundred CHIR genes that are further dist
 inguished into activating\, inhibitory and bifunctional receptors.   Compa
 risons of various features such as amino acid motifs\, genomic structure\,
  expression and associated adaptor molecules reveal the homology of CHIR t
 o both the killer Ig-like and the leukocyte Ig-like receptor families\, wi
 th most pronounced correlation of certain CHIR to the NK cell receptor KIR
 2DL4.\n\nTo date the CHIR ligands remain largely obscure with the exceptio
 n of CHIR-AB1 that binds to chicken IgY.   Detailed analyses of CHIR-AB1\,
  its crystal structure\, the interaction to IgY and functional capabilitie
 s allow us to draw conclusions regarding Fc receptor phylogeny and functio
 n.   
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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