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SUMMARY:The Aryl Hydrocarbon Receptor: an interpreter of the micro-environ
 ment - Dr Marc Veldhoen\, Babraham Institute\, Cambridge
DTSTART:20120229T123000Z
DTEND:20120229T133000Z
UID:TALK35127@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:The transcription factor aryl hydrocarbon receptor (AhR) is se
 lectively expressed in some immune cells\, importantly in both Th17 and ga
 mma/delta T cells. Its activation is important for optimal development of 
 the Th17 cell subset and results in enhanced activation of both Th17 and I
 L-17 producing gamma/delta T cells. \n\nImmune protection against invading
  microorganisms starts at epithelial barrier sites. At these sites reside 
 specialised intra-epithelial lymphocytes (IELs) that are important not onl
 y as a first line of defence but also in epithelial barrier organisation a
 nd wound repair. Especially at epithelial sites\, AhR activation in respon
 se to endogenous and exogenous ligands may constitute a way in which envir
 onmental stimuli could affect the immune status. \n\nNew data regarding th
 e role of such stimulation will be discussed.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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