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SUMMARY:Memory CD4 T cell generation and survival within secondary lymphoi
 d tissue - Dr David Withers\, University of Birmingham
DTSTART:20120307T123000Z
DTEND:20120307T133000Z
UID:TALK35129@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:CD4 T cell responses are initiated within secondary lymphoid t
 issue and it is within this tissue that memory CD4 T cells remain. Maintai
 ning memory CD4 T cells is pivotal to the success of vaccination. By analy
 sing physiological CD4 T cell responses\, using a combination of MHC II te
 tramers and transfers of small numbers of TCR transgenic T cells\, we are 
 dissecting the signals and cells required for the generation and survival 
 of memory CD4 T cells. Mice deficient in lymphotoxin  receptor\, which 
 lack the characteristic architecture of secondary lymphoid tissue\, are un
 able to maintain memory CD4 T cells\, indicating that cellular interaction
 s are important for this persistence. \n\nWe have identified lymphoid tiss
 ue inducer cells\, a RORgamma-dependent population responsible for the for
 mation of lymph nodes\, as key cells in sustaining memory CD4 T cells with
 in secondary lymphoid tissue. Although primary responses appear normal in 
 the absence of RORgamma\, antigen specific memory CD4 T cells do not persi
 st and these mice cannot mount memory antibody responses.  Transfer of ant
 igen-specific memory CD4 T cells into mice with or without lymphoid tissue
  inducer cells demonstrated that these cells were sufficient for maintaini
 ng memory CD4 T cells\, likely through provision of OX40L signals. \n\nWe 
 are currently further analysing the role of lymphoid tissue inducer cells 
 within CD4 T cell responses and investigating the requirement for costimul
 atory molecules. \n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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