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SUMMARY:Natural Killers or Natural Protectors? The Role of NK cells During
  Intestinal Inflammation - Dr Lindsay Hall\, University of East Anglia
DTSTART:20120208T123000Z
DTEND:20120208T133000Z
UID:TALK35215@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:In addition to their more traditional role in innate immunity\
 , such a tumour surveillance and viral clearance\, recent studies have ind
 icated that NK cells also modulate responses during chronic inflammatory d
 isease. However\, due to conflicting reports and lack of clear data from i
 n vivo models the role of NK cells in this context remains uncertain. Ulce
 rative colitis (UC) is a chronic relapsing and remitting inflammatory cond
 ition of the large bowel with an approximate prevalence of 1:1000 in devel
 oped countries and increases with socioeconomic development. While the pat
 hogenesis of UC is still incompletely understood\, previous work indicated
  a complex interplay of genetic and environmental factors with a dysregula
 ted immune response. A characteristic pathological finding in the inflamed
  mucosa of experimental colitis models and UC patients is dense neutrophil
  infiltration and associated production of reactive oxygen species.\n\nI w
 ill discuss a previously undescribed immunoregulatory mechanism of action 
 of NK cells by attenuating neutrophil-mediated tissue injury during intest
 inal inflammation. \n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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