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SUMMARY:Genome-wide RNAi and HCS Microscopy approaches to dissect membrane
  traffic pathways - Professor Jez Simpson\, University College Dublin
DTSTART:20120315T143000Z
DTEND:20120315T153000Z
UID:TALK35294@talks.cam.ac.uk
CONTACT:Alison Read
DESCRIPTION:In cells molecules are transported between membrane-bounded co
 mpartments through the process of membrane traffic. Due to the exquisite m
 orphology and distribution of organelles in mammalian cells\, imaging appr
 oaches are highly suited to the study of these transport pathways. Using a
  combination of genome-wide RNA interference and automated high content sc
 reening microscopy we have systematically analysed and quantified the rela
 tive contribution of all human genes to the process of secretory transport
 . Our approach also provides information on the organisation of membranes 
 in the secretory pathway\, the subcellular localisation of novel players\,
  and reveals new networks of proteins associated with the regulation of me
 mbrane traffic function.
LOCATION:Part II room\,  Department of Genetics
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