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SUMMARY:Next generation sequencing facilitates the interpretation of the h
 uman genome. - Stefan Gräf
DTSTART:20120216T131000Z
DTEND:20120216T140000Z
UID:TALK35383@talks.cam.ac.uk
CONTACT:Sven Friedemann
DESCRIPTION:In biology astronomical amounts of genomic information has bee
 n and continues to be generated due to the rapid development of novel\, fa
 ster\, and cheaper DNA sequencing technologies. The leading challenges of 
 21st century biology lie in the interpretation and integration of these da
 ta using computational genomics approaches. Especially the sequencing of i
 ndividual human genomes aims to gain a deeper understanding of the persona
 l biology of our genomes in health and disease. Beyond the information enc
 oded by the raw DNA sequence there are additional layers of epigenetic cod
 es that play important roles. In this Darwin College Science Group Seminar
  I will give a brief overview on the organisation of the genome and how in
 formation is epigenetically encoded with respect to it's biology. Then I w
 ill describe how this information can be obtained using the current high-t
 hroughput next-generation sequencing technology. I will close with an exam
 ple of a project that investigates the association of non-protein-coding R
 NAs with chromatin in relation to the initiation of DNA replication.
LOCATION:Entertaining Room\, Darwin College
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