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SUMMARY:Increased methylation variation across cancer types - Kasper Danie
 l Hansen (Johns Hopkins)
DTSTART:20120113T160000Z
DTEND:20120113T170000Z
UID:TALK35395@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:DNA methylation is a widely studied epigenetic mark known to b
 e\nimplicated in tissue differentiation and disease\, specifically cancer.
 \nWe show stochastic variation in this epigenetic mark across cancer types
 .  We use shotgun bisulfite sequencing of 3 paired tumor-normal colon canc
 er samples to profile DNA methylation genomewide.  This reveals the struct
 ure of local\, small-scale epigenetic changes in cancer.  We also show hyp
 o-methylation of large scale genomic domains encompassing more than half t
 he genome.  The computational methods used to discover these aberrations w
 ill be described.\n\nHosted by Rory Stark.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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