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SUMMARY:Crick Lecture 2012: Consequences of Aneuploidy - Angelika Amon\, H
 HMI\, MIT
DTSTART:20120215T161500Z
DTEND:20120215T180000Z
UID:TALK35551@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Aneuploidy is defined as a chromosome number that is not a mul
 tiple of the haploid complement. Almost a century ago\, Theodor Boveri sug
 gested a possible link between aneuploidy and cancer\, a disease associate
 d with high proliferative ability. On the other hand\, aneuploidy at the o
 rganismal level is associated with severe developmental abnormalities and 
 death in all species analyzed to date. These results raise an interesting 
 conundrum. How is it possible that the presence of a single additional chr
 omosome is associated with developmental defects characterized by growth r
 estriction\, yet in the context of cancer severe karyotypic abnormalities 
 exist in cells with high proliferative abilities? To shed light on the rel
 ationship between aneuploidy and cancer we determined how aneuploidy affec
 ts the physiology and differentiation of normal cells. We generated 20 str
 ains of budding yeast and 4 primary mouse cell lines bearing an extra copy
  of one or more of chromosomes. The analysis of these cell lines revealed 
 chromosome specific phenotypes and traits shared by most aneuploid cell li
 nes and strains. The importance of these characteristics in tumor evolutio
 n and development of new treatment strategies will be presented.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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