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SUMMARY:New concepts in host-pathogen interactions: lessons from Listeria 
 - Pascale Cossart\, Institute Pasteur\, Paris
DTSTART:20120202T161500Z
DTEND:20120202T180000Z
UID:TALK35553@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Pathogens have long co-evolved with their host and have devise
 d elegant and efficient strategies to exploit to their own profit molecule
 s or mechanisms critical for the host. The study of these strategies has l
 ed not only to the discovery of amazing tricks used by pathogens during in
 fection but also to that of unsuspected mechanisms normally used by the ce
 ll. Pathogens thus appear as very powerful tools to address critical issue
 s in Cell Biology. We will illustrate this duality by presenting several a
 spects of the infection by Listeria monocytogenes\, a food borne bacterium
  which is able to invade mammalian cells and spread directly form cell to 
 cell. Other bacteria will also be discussed.\nWe will first show how Liste
 ria orchestrates its entry into cells\, and will present the discovery of 
 an unsuspected role of clathrin in the early cytoskeleton rearrangments le
 ading to internalization. We will also discuss how septins are increasingl
 y recognized as important components of the cytoskeleton and as such also 
 control the Listeria entry process. Interestingly\, septins are able to en
 trap some cytosolic bacteria able to move from cell to cell such as Shigel
 la but not Listeria in a process tighly coupled to autophagy and which lim
 its their actin-based dissemination. \nFinally\, we recently discovered th
 at Listeria can reprogram its host by injecting into the infected cell a p
 rotein that interact with a previously unknown heterochromatinisation fact
 or and prevent its action raising the possibility that chromatin marks cou
 ld remain after infection. A new field of investigation\, i.e. chromatin r
 emodeling by pathogens and a new discipline « pathoepigenetics » are eme
 rging. \n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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