BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Explaining the age pattern of immunity to seasonal influenza - Ada
 m Kucharski\, DAMTP
DTSTART:20120430T103000Z
DTEND:20120430T113000Z
UID:TALK35955@talks.cam.ac.uk
CONTACT:Prof. Julia Gog
DESCRIPTION:The age pattern of immunity to seasonal influenza is striking 
 but little understood. In contrast to many infections\, the proportion of 
 the population seropositive peaks in school age children\, reaches a minim
 um between ages 35-65\, and then rises again in older age groups. Heteroge
 neous mixing between age classes can have a profound effect on disease dyn
 amics\, and is hence the obvious candidate explanation for this pattern. H
 owever\, using a mathematical model of multiple influenza strains\, age de
 pendent transmission based on mixing data from social contact surveys cann
 ot on its own explain the observed data. Instead\, seroprevalence may be a
  consequence of ‘original antigenic sin’\; if the first infection of a
  lifetime dominates subsequent immune responses\, it is possible to reprod
 uce the relationship between age and immunity.
LOCATION:DD47\, Cripps Court\, Queens' College
END:VEVENT
END:VCALENDAR