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SUMMARY:Identification of circadian mutants with an altered response to ni
 cotinamide - Timothy Hearn
DTSTART:20120518T123000Z
DTEND:20120518T130000Z
UID:TALK36380@talks.cam.ac.uk
CONTACT:Suzy Stoodley
DESCRIPTION:The plant circadian system consists of a network of input sign
 als\, output rhythms and a molecular clock\, which interact to create a ro
 bust oscillator. This oscillator fine tunes biological processes to maximi
 se plant fitness\, and is therefore of great interest to modify to create 
 stress tolerant crops. Previous work has shown that circadian oscillations
  of cytosolic calcium form both an output and an input into the oscillator
 \, and are inhibited by the small metabolite nicotinamide. This is likely 
 to be due to inhibition of an ADP-ribosyl cyclase\, which produces the cal
 cium mobilising agent cyclic adenosine diphosphoribose (cADPR). Nicotinami
 de has also been shown to inhibit poly-ADP ribose polymerases (PARPs)\, an
 d Sirtuins\, a class of NAD-dependent histone deacetlyases. In addition to
  abolition of calcium oscillations nicotinamide causes a period lengthenin
 g effect on other circadian outputs. In this talk I will discuss the forwa
 rd genetics approach being taken to discover novel components in this path
 way\, and the screening tools that we have developed to identify mutants w
 ith an altered response to nicotinamide.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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