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SUMMARY:Defining the role of NAD+ metabolism in circadian clock function i
 n Arabidopsis thaliana - Laura Bell
DTSTART:20120524T153000Z
DTEND:20120524T160000Z
UID:TALK36398@talks.cam.ac.uk
CONTACT:Suzy Stoodley
DESCRIPTION:The circadian clock is an endogenous mechanism synchronising t
 he timing of biological processes with daily fluctuations in the environme
 nt. Previous work in the lab has demonstrated that in Arabidopsis thaliana
 \, [Ca2+]cyt participates in a feedback  loop within the clock\, mediated 
 by the Ca2+-releasing agent cyclic adenosine diphosphate ribose (cADPR). c
 ADPR is synthesised from nicotinamide adenine dinucleotide (NAD+) by the e
 nzyme ADPR cyclase\, releasing nicotinamide as a by-product. Nicotinamide 
 treatment abolishes circadian oscillations of [Ca2+]cyt and lengthens the 
 period of other clock outputs by inhibiting ADPR cyclase.\n\nPARPs and sir
 tuins are other classes of enzymes which also consume NADplus and are inhi
 bited by nicotinamide. We are investigating which of these pathways is res
 ponsible for the connection to circadian signalling\, and is the target of
  nicotinamide with respect to the clock. We are testing the hypothesis tha
 t alterations in NADplus levels\, and consequently cADPR\, results in alte
 red clock behaviour due to disturbed [Ca2+]cyt rhythms\, therefore couplin
 g NAD+ metabolism and the circadian clock.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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