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SUMMARY:The impact of protease-regulated antigen processing and presentati
 on - Dr Timo Burster\, Ulm University
DTSTART:20120320T130000Z
DTEND:20120320T140000Z
UID:TALK36981@talks.cam.ac.uk
CONTACT:Dr Robert Busch
DESCRIPTION:Three lines of inquiry will be presented. The first part of th
 is talk will focus on the role of the serine protease\, cathepsin G\, in p
 rocessing of antigens for presentation to CD4+ T cells by MHC class II mol
 ecules.  A novel affinity probe was used to demonstrate that cathepsin G e
 nzymatic activity is elevated in antigen-presenting cells from patients wi
 th type 1 diabetes.  This enzyme was shown to play a major role in the pro
 cessing of proinsulin\, an important diabetes autoantigen\, into fragments
  recognised by patients' CD4+ T cells.  In a second line of investigation\
 , cathepsin G cleaved detergent-solubilised and recombinant soluble\, but 
 not membrane-bound MHC class II molecules\, raising the possibility that t
 his enzyme may initiate the disposal of class II molecules dislocated from
  the plasma membrane.  Finally\, Epstein-Barr virus was shown to evade imm
 une recognition by CD4+ T cells in part by modulating the level of catheps
 in D\, an aspartyl protease.\n
LOCATION:Rheumatology Seminar Room\, Dept of Medicine\, Addenbrooke's Hosp
 ital
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