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SUMMARY:SAXS studies on biological molecules at Diamond Light Source - Ino
 ue Katsuaki\, DLS\, UK
DTSTART:20120425T091500Z
DTEND:20120425T101500Z
UID:TALK37066@talks.cam.ac.uk
CONTACT:23791
DESCRIPTION:The small angle X-ray scattering (SAXS) covers the major disci
 plines of biology\, chemistry and physics delivering structural and dynami
 c information in nanoscience\, mesoscopic architectures\, supramolecular s
 tructures\, and nucleation/growth of crystals. The increased need for SAXS
  in biological sciences follows the recognition that many proteins are not
  amenable to crystallisation. They may however be characterised in part by
  SAXS where the molecular envelope can be used to constrain model building
  from NMR and MX data. Furthermore transient structures and structures wit
 h inherent flexibility are more amenable to SAXS for study than MX or NMR.
  Also\, a simultaneous recording of both SAXS and WAXS (wide angle X-ray s
 cattering) techniques in combination allows users to probe length scales r
 anging from a few Angstroms to several microns with high resolution. At th
 e synchrotron facility\, Diamond Light Source\, one SAXS beamline (I22: No
 n-crystalline Diffraction) is operating and another one (B21: HATSAXS) is 
 now under construction. On I22\, the high brilliance of the insertion devi
 ce source allows structural investigation of materials under extreme envir
 onments. I22 provides reliable access to millisecond and shorter time scal
 es\, essential to understanding kinetic processes such as early folding ev
 ents\, ligand binding and molecular interactions in proteins and other bio
 logical molecules. On B21\, the highly automated throughput measurements w
 ith the highest possible reliability and accuracy will be expected to perf
 orm successfully. The construction of this beamline will end in the second
  half of 2012\, and will be open for users in early 2013 after the commiss
 ioning. A large variety of SAXS measurements would be expected to perform 
 with the efficient use of these two beamlines. The development and improve
 ment of software for Scattering data handling and analysis is progressed s
 uccessfully along with the operation and the construction of beamlines. So
 me practical examples of SAXS data handling including molecular modelling 
 would be shown at the seminar. 
LOCATION:Perham's seminar room
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