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SUMMARY:&quot\;The impact of protease-regulated antigen processing and pre
 sentation&quot\; - Dr Timo Burster\, University of Ulm. Hosted by Dr Rober
 t Busch
DTSTART:20120320T130000Z
DTEND:20120320T140000Z
UID:TALK37068@talks.cam.ac.uk
CONTACT:Catie Heathfield
DESCRIPTION:Three lines of inquiry will be presented. The first part of th
 is talk will focus on the role of the serine protease\, cathepsin G\, in p
 rocessing of antigens for presentation to CD4+ T cells by MHC class II mol
 ecules.  A novel affinity probe was used to demonstrate that cathepsin G e
 nzymatic activity is elevated in antigen-presenting cells from patients wi
 th type 1 diabetes.  This enzyme was shown to play a major role in the pro
 cessing of proinsulin\, an important diabetes autoantigen\, into fragments
  recognised by patients' CD4+ T cells.  In a second line of investigation\
 , cathepsin G cleaved detergent-solubilised and recombinant soluble\, but 
 not membrane-bound MHC class II molecules\, raising the possibility that t
 his enzyme may initiate the disposal of class II molecules dislocated from
  the plasma membrane.  Finally\, Epstein-Barr virus was shown to evade imm
 une recognition by CD4+ T cells in part by modulating the level of catheps
 in D\, an aspartyl protease.\n\nDr Burster studied biology at the Universi
 ties of Freiburg and Tuebingen\, obtaining his PhD in Immunology in 2003. 
  Following postdoctoral research at Stanford University (2003-6)\, he beca
 me a Group Leader at the Dept of Internal Medicine at the University of Ul
 m(2006-11).  He obtained his university teaching qualification (Habilitati
 on) in Experimental Medicine in 2010 and currently holds an honorary facul
 ty position (Privatdozent) at the Ulm University.
LOCATION:Rheumatology Seminar Room\, Dept of Medicine\, Level 5\,
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