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SUMMARY:Monitoring protein synthesis one codon at a time through ribosome 
 profiling - Jonathan Weissman\, Howard Hughes Medical Institute\, UCSF
DTSTART:20120510T151500Z
DTEND:20120510T170000Z
UID:TALK37284@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The ability to sequence genomes has far outstripped approaches
  for deciphering the information they encode. We have developed a suite of
  techniques based on ribosome profiling (deep sequencing of ribosome prote
 cted fragments) that dramatically expand our ability to follow translation
  in vivo. I will present recent applications of our ribosome profiling app
 roach including the following: (1) Development of ribosome profiling proto
 cols for a wide variety of eukaryotic and prokaryotic organisms. (2) Uses 
 of ribosome profiling to globally monitor when chaperones\, targeting fact
 ors or processing enzymes engage nascent chains. (3) Deciphering the drivi
 ng force and biological consequences underlying the choice of synonymous c
 odons. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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