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SUMMARY:Phylogenetic origin of the vertebrate leukocyte receptors - Prof D
 r Louis Du Pasquier\, University of Basel
DTSTART:20120523T113000Z
DTEND:20120523T123000Z
UID:TALK37360@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Adaptive immunity of vertebrates is centered on leukocytes\, l
 ymphocytes and other cells of the hematopoietic system like the antigen pr
 esenting cells.\n\nBy scrutinizing the data bases of various invertebrates
 \, from Cnidarians to Tunicates\, genes related to the receptors that buil
 d the different leukocyte lineages of vertebrates have been found (only le
 ctins and immunoglobulin superfamily members have been investigated)\, som
 etimes with high homology and often on conserved linkage groups. One of th
 ese linkage groups is that of the leukocyte receptor complex and neighbour
 ing region of the human chromosome 19q and 3 proposed paralogs. \n\nFollow
 ing the hypothesis of 2 genome duplications occurring during the evolution
  of chordates one could imagine that preduplication ancestors should have 
 only one such region.   Indeed it seems to be the case in the tunicate Cio
 na.   So\, perhaps\, the basic leukocyte population context of the future 
 vertebrates was common to the ancestor of both jawless and jawed vertebrat
 es\, that ultimately diverged by the choice of different protein families 
 for generating somatically their specific antigen receptors.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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