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SUMMARY:Insights into human papillomavirus persistence and cervical carcin
 ogenesis from the W12 model system - Professor Nick Coleman\, Dept of Path
 ology\, Cambridge
DTSTART:20120530T113000Z
DTEND:20120530T123000Z
UID:TALK37361@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Cervical carcinoma is the third most common cause of cancer-re
 lated deaths in women worldwide. The full impact of vaccination against hi
 gh-risk human papillomavirus (HRHPV) will not be seen for ~20 years and th
 ere will be no benefits for women who are already HRHPV positive. Current 
 treatments for cervical carcinoma have not changed for decades and surviva
 l rates for advanced disease remain low. \n\nOur group investigates key ev
 ents in the development of cervical squamous cell carcinoma (SCC) followin
 g infection with HRHPV\, using clinical samples and the W12 in vitro model
  system. We study mechanisms of viral persistence in cervical epithelial c
 ells\, causes of deregulated viral transcription in proliferating epitheli
 um and the significance of common host genomic changes induced by over-exp
 ressed HRHPV oncogenes. \n\nWe recently identified that cervical keratinoc
 ytes containing HPV16 episomes show specific inhibition of responses to ds
 RNA through down-regulation of TLR3 and RIG-I receptors and that the oncos
 tatin M receptor is commonly over-expressed in cervical carcinomas and con
 tributes significantly to disease progression.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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