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SUMMARY:The structural and mechanistic basis for Rab cycling and targeting
  - Roger Goody\, MPI Dortmund
DTSTART:20120521T151500Z
DTEND:20120521T170000Z
UID:TALK38128@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The Rab proteins are members of the Ras superfamily of small G
 TPases and are important regulators of intracellular vesicular transport. 
 Like other members of this superfamily\, they are involved in a cycle of G
 TPase and GDP exchange activity and also in a coupled cycle of reversible 
 attachment to and detachment from membranes. These 2 cycles form the basis
  for coordination of a complex group of both generic and specific protein-
 protein as well as protein-membrane interactions. They are being studied b
 y structural and kinetic/spectroscopic methods. Results to be discussed in
 clude those pertaining to the process of Rab prenylation\, an essential re
 quirement for their interaction with membranes\, delivery of Rab proteins 
 to membranes and the reverse process of extraction\, as well as exchange o
 f GDP for GTP catalyzed by guanine nucleotide exchange factors (GEFs). Par
 ticular emphasis will be placed on understanding the processes involved in
  Rab cycling and targeting and structural and kinetic results addressing t
 he question of GEF and GDF (GDI displacement factor) activities will be pr
 esented. An additional\, related topic concerns the manner in which these 
 processes are modified by proteins from Legionella pneumophila. These prot
 eins affect Rab function by both covalent and non-covalent processes and u
 nderstanding these effects provides insight not only into events occurring
  during Legionella infection but also into the fundamental physiological p
 rocesses referred to above.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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