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SUMMARY:“New Insights into the Mechanisms and Selectivity of Protein Deg
 radation by the Proteasome Pathway” - Alfred Lewis Goldberg - Professor 
 of Cell Biology\, Harvard Medical School ( guest of St Johns College)
DTSTART:20120515T093000Z
DTEND:20120515T110000Z
UID:TALK38227@talks.cam.ac.uk
CONTACT:Alison Read
DESCRIPTION:Fred has been fascinated by protein degradation pathways since
  his first days as a professor at Harvard In the 1970’s. The general opi
 nion at the time was that the cell’s garbage collection was mostly done 
 by the lysosome.\n\nAlways pushing at the frontiers of cell biology\, Fred
  discovered the proteasome and then it’s famous inhibitor MG--‐132.\n\
 nWith careful chemical manipulations his group was able to generate the re
 lated compound bortezomib that is now a billion dollar drug used for the t
 reatment of a haematological cancer called myeloma.\n
LOCATION:Part II room\,  Department of Genetics
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